Clearing the smoke: What do we know about adolescent cannabis use and
schizophrenia?
“What can be said is that the extreme opinions on this subject are not rooted in
science. There is little evidence that, at a population level, cannabis use during
adolescence is a primary contributing factor in the development of psychiatric illness.
In fact, it has even been suggested that at a societal level, the prevention of 3000-
4000 adolescents from consuming cannabis may prevent only 1 case of psychosis
from emerging. At the same time, however, there is evidence that in high-risk
populations, cannabis can be highly adverse, so arguments claiming that cannabis is
innocuous are equally flawed… once a diagnosis of schizophrenia is present,
cannabis use is clearly adverse”.
Clearing the smoke: What do we know about adolescent cannabis use and schizophrenia?
Cannabinoids for the treatment of dementia (Review)
This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2009, Issue 2
What is the lethal dose of marijuana? (cannabis)
“In summary, enormous doses of Delta 9 THC, All THC and concentrated marihuana
extract ingested by mouth were unable to produce death or organ pathology in large
mammals but did produce fatalities in smaller rodents due to profound central
nervous system depression.”
“The non-fatal consumption of 3000 mg/kg A THC by the dog and monkey would be
comparable to a 154-pound human eating approximately 46 pounds (21 kilograms) of
1%-marihuana or 10 pounds of 5% hashish at one time. In addition, 92 mg/kg THC
intravenously produced no fatalities in monkeys. These doses would be comparable
to a 154-pound human smoking at one time almost three pounds (1.28 kg) of 1%-
marihuana or 250,000 times the usual smoked dose and over a million times the
minimal effective dose assuming 50% destruction of the THC by smoking.”
“Thus, evidence from animal studies and human case reports appears to indicate that
the ratio of lethal dose to effective dose is quite large. This ratio is much more
favourable than that of many other common psychoactive agents including alcohol and
barbiturates (Phillips et al. 1971, Brill et al. 1970).”